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JULY 10, 2025

Debating Mixing Local Anesthetics: Best of Both Worlds or Playing With Fire?

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ORLANDO, Fla.—Should anesthesiologists mix local anesthetics for peripheral nerve blocks (PNBs)? The complicated, often contentious issue was debated during a session at the American Society of Regional Anesthesia and Pain Medicine 2025 annual spring meeting.

During the discussion, experts weighed in on which approach maximizes anesthetic benefits while ensuring patient safety.

Best of Both Worlds

In essence, the argument for mixing local anesthetics centers around the ability to utilize the