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AUGUST 14, 2025

The Frost Series: Bradycardia and Cardiac Arrest After Sugammadex in a Patient With Renal Failure

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John Le, MD
Associate Clinical Professor
Kenneth Liu, MD
Associate Clinical Professor
Department of Anesthesiology
David Geffen School of Medicine at UCLA
Olive View-UCLA Medical Center
Los Angeles
Editor: Karen Sibert, MD

Sugammadex is widely used for reversal of muscle relaxation with steroidal neuromuscular blocking agents including rocuronium. We report the rapid onset of bradycardia and cardiac arrest after the administration of sugammadex to a patient with end-stage renal disease (ESRD). The