In this video abstract recap, the authors analyzed the analgesic effects and complete gastrointestinal (GI) response between oliceridine (Olinvyk, Trevena), morphine and placebo in two phase 3 studies of patients with moderate to severe acute pain after bunionectomy or abdominoplasty.
To conduct these trials, the researchers randomized patients into five groups to receive different IV demand dosing regimens—oliceridine 0.1 mg, oliceridine 0.35 mg, oliceridine 0.5 mg, morphine 1 mg or