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MAY 10, 2021

Gabapentinoids Increase the Risk for Opioid-Related Adverse Events

Originally published by our sister publication, Pain Medicine News

Surgical patients who were treated with both opioids and gabapentinoids (gabapentin or pregabalin) on the day of surgery were nearly twice as likely to experience an opioid overdose and 70% more likely to incur respiratory complications, compared with patients who received opioids only, according to a cohort study in JAMA Network Open (2020;3[12]:e2031647).

However, the risk for encountering these events was quite low: less than