Originally published in our sister publication, Pain Medicine News.
A new study has concluded that a marked portion of surgical patients are receiving prescriptions for opioids to which they may have limited response due to impaired function of the CYP2D6 enzyme.
Nearly all of these individuals received hydrocodone, which the authors said has a “controversial” pharmacogenetic relationship with cytochrome P450 2D6 (CYP2D6).
As Daniel B. Larach, MD, MTR, MA, explained, variations in the