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APRIL 21, 2025

Liposomal Bupivacaine Reduces Opioid Consumption After Liver Resection

PHILADELPHIA—Thoracic paravertebral block with liposomal bupivacaine (Exparel, Pacira BioSciences) reduces total postoperative opioid consumption relative to standard bupivacaine plus dexamethasone in patients undergoing liver resection, according to the results of a new study. However, the trial found differences between groups within a number of other end points.

“Liver resection is a very painful procedure and is typically associated with a large consumption of opioids during the