Christopher F. Tirotta, MD
New research has concluded that the 4-mg/kg dose of liposomal bupivacaine (Exparel, Pacira) is safe in pediatric patients undergoing spine or cardiac surgery.
The study found that plasma bupivacaine levels following local infiltration of the agent remained below toxic thresholds after both procedures in these patients.
“We know pediatric patients can experience moderate to severe pain after surgery, and the ASA [American Society of Anesthesiologists] and other