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FEBRUARY 28, 2023

Chronic Opioid Utilization Increases Mortality From Sepsis

NEW ORLEANS—Chronic opioid utilization in excess of 20 average daily morphine milligram equivalents (MME) in patients who are subsequently hospitalized with sepsis is independently associated with increased odds of in-hospital mortality, according to the results of a new study.

Given these findings, the researchers recommended the use of multimodal therapeutic approaches in this high-risk patient population.

“Emerging research has shown that opioids have immunomodulating qualities,