Cytochrome P450 (CYP) metabolism plays a paramount role in systemic concentrations of oxycodone in children, according to interim results from an ongoing Boston Children’s Hospital study. These results, the researchers concluded, demonstrate the need to consider genetic variations that may affect the way children metabolize the drug, sometimes to a tragic end.
“Back in 2007, there were two case reports of children who had tonsillectomies, went home on oral codeine, had apnea and