Bupivacaine-Meloxicam Combination Provides Better Opioid–Sparing Pain Control Than Bupivacaine HCl Alone

Newly FDA-approved bupivacaine-meloxicam combination (Zynrelef, Heron Therapeutics) showed a significant reduction in both pain and opioid use in older adults undergoing a bunionectomy or hernia repair, compared with bupivacaine hydrochloride (HCl) or placebo. This finding (Pain Manag 2021 Jul 21. doi:org/10.2217/pmt-2021-0043) comes from a post hoc analysis of two earlier, pivotal bupivacaine-meloxicam trials (Reg Anesth Pain Med 2019 May 21. doi:10.1136/rapm-2019-100531; Hernia